Objectives. To evaluate and compare the efficacy, safety, hydrating properties, and tolerability of 10% lactic acid (LA) and 5%salicylic\nacid (SA) in the therapy of keratosis pilaris (KP).Material andMethod. Patients with KP were randomized for treatment with either\n10% LA or 5% SA creams being applied twice daily for 3 months. The patients were clinically assessed at baseline and after 4, 8, and\n12 weeks of treatment and 4 weeks after treatment. The functional properties of the stratum corneum (SC) were determined before\ntreatment, 12 weeks, and follow-up phase by high-frequency conductance and transepidermal water loss (TEWL). Results. At the\nend of the trial, the mean reduction of the lesions from baseline was statistically significant for 10% LA (66%) and 5% SA (52%).\nDuring the treatment, higher conductance values were found on both group and this improvement was maintained until the follow\nup period. No significant differences in transepidermal water loss were observed after treatment. The adverse effects were limited\nto mild irritation localized on the skin without systemic side effect. Conclusion. The study demonstrated that 10% LA and 5% SA\nare beneficial to treat KP with the significantly clearance and marked improvement as by instrumental evaluation.
Loading....